New Biocompatible Frameworks: Small-Molecule HOFs Open the Door to Advanced Bio-Applications In a notable advance bridging chemistry, materials science and biotechnology, researchers have developed a new class of highly ordered, macroporous frameworks built from small, biocompatible molecules. These frameworks — a type of Hydrogen‑bonded Organic Frameworks (HOFs) — combine structural robustness, large pore sizes, and…
Small-Molecule Enhancer of Secreted Clusterin: A Promising New Approach to Alzheimer’s Therapy Researchers have identified a small-molecule drug candidate that boosts levels of a naturally protective brain protein and restores memory in Alzheimer’s disease (AD) mouse models — offering a fresh therapeutic angle beyond the traditional amyloid- or tau-centric approaches. Why Clusterin Matters The protein…
Small-Molecule Inhibitor of RNA-Binding Protein IGF2BP3 — a Potential New Weapon Against Hard-to-Treat Leukaemias Researchers have recently identified a small-molecule inhibitor of the RNA-binding protein IGF2BP3 that shows potent anti-leukemic activity — a breakthrough that may pave the way for new treatments against leukaemias and other difficult-to-target cancers. Background — Why IGF2BP3 Matters IGF2BP3 is…